| Entry |
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| Symbol |
CRHR1, CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRHR, CRHR1L
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| Name |
(RefSeq) corticotropin releasing hormone receptor 1
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| KO |
| K04578 | corticotropin releasing hormone receptor 1 |
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| Organism |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Network |
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| Element |
| N00324 | CRHR-PKA-ACTH signaling pathway |
| N00327 | Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04024 cAMP signaling pathway
1394 (CRHR1)
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
1394 (CRHR1)
09150 Organismal Systems
09156 Nervous system
04730 Long-term depression
1394 (CRHR1)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
1394 (CRHR1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:hsa04030]
1394 (CRHR1)
G protein-coupled receptors [BR:hsa04030]
Secretin receptor family
Hypothalamic hormone
Corticotropin-releasing hormone (CRH)
1394 (CRHR1)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
17:45784320..45835828
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| AA seq |
444 aa
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV |
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| NT seq |
1335 nt +upstreamnt +downstreamnt
atgggagggcacccgcagctccgtctcgtcaaggcccttctccttctggggctgaacccc
gtctctgcctccctccaggaccagcactgcgagagcctgtccctggccagcaacatctca
ggactgcagtgcaacgcatccgtggacctcattggcacctgctggccccgcagccctgcg
gggcagctagtggttcggccctgccctgcctttttctatggtgtccgctacaataccaca
aacaatggctaccgggagtgcctggccaatggcagctgggccgcccgcgtgaattactcc
gagtgccaggagatcctcaatgaggagaaaaaaagcaaggtgcactaccatgtcgcagtc
atcatcaactacctgggccactgtatctccctggtggccctcctggtggcctttgtcctc
tttctgcggctcaggccaggctgcacccattggggtgaccaggcagatggagccctggag
gtgggggctccatggagtggtgccccatttcaggttcgaaggagcatccggtgcctgcga
aacatcatccactggaacctcatctccgccttcatcctgcgcaacgccacctggttcgtg
gtccagctaaccatgagccccgaggtccaccagagcaacgtgggctggtgcaggttggtg
acagccgcctacaactacttccatgtgaccaacttcttctggatgttcggcgagggctgc
tacctgcacacagccatcgtgctcacctactccactgaccggctgcgcaaatggatgttc
atctgcattggctggggtgtgcccttccccatcattgtggcctgggccattgggaagctg
tactacgacaatgagaagtgctggtttggcaaaaggcctggggtgtacaccgactacatc
taccagggccccatgatcctggtcctgctgatcaatttcatcttccttttcaacatcgtc
cgcatcctcatgaccaagctccgggcatccaccacgtctgagaccattcagtacaggaag
gctgtgaaagccactctggtgctgctgcccctcctgggcatcacctacatgctgttcttc
gtcaatcccggggaggatgaggtctcccgggtcgtcttcatctacttcaactccttcctg
gaatccttccagggcttctttgtgtctgtgttctactgtttcctcaatagtgaggtccgt
tctgccatccggaagaggtggcaccggtggcaggacaagcactcgatccgtgcccgagtg
gcccgtgccatgtccatccccacctccccaacccgtgtcagctttcacagcatcaagcag
tccacagcagtctga |
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